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讲座:Determinants of abnormal metabolism-BOLD-interaction in major depression and their modulation by NMDA antagonists

发布日期:2015-11-28   浏览次数

 

讲人:Dr. Martin Walter

Martin Walter博士,德国精神病学和心理分析执照医生,德国图宾根大学精神科教授,天津精神卫生中心客座 教授,中科院自动化所外籍学者,德国莱布尼茨神经生物学研究所临床情绪影像学实验室负责人。多家SCI杂志的编辑,如Psychiatry Journal, PlosOne, Frontiers in Neuropsychiatric等。从2007年开始在诸如Journal of Neuroscience, JAMA PsychiatryNature Neuroscience的国际期刊上发表了104篇论文,总引用率超过3000

 内容简介:

Introduction:

Multimodal investigations allow us to go further when interpreting the neurobiological meaning of observed effects in BOLD Signal changes or functional connectivity. We use combinations of Magnetic Resonance Spectroscopy (MRS) and fMRI from 3T to 7T to compare the inter-individual variation in classical fMRI markers with changes in concentrations of GABA, Glutamate or Glutamine. We further investigate neural mechanisms of action of the recently described antidepressant substance ketamine. Here we investigate the mechanisms of synaptic plasticity from the molecular to the whole brain systems level in healthy controls. Using combined imaging modalities at 7T, we try to shed light on glutamatergic modulation of learning processes and plasticity, in systems with specific sensitivity to NMDAergic modulation. These brain systems are further investigated for their contribution of other symptoms associated with intravenous application of NMDA antagonists. In treatment resistant patients, we try to reveal markers of clinical change as well as predictors of treatment outcome which might, in the future guide clinical decisions in these severely affected patients.

 

时间:121日(周二)下午3:00

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